Molecular imaging of Bcr-Abl phosphokinase in a xenograft model
نویسندگان
چکیده
منابع مشابه
Molecular imaging of Bcr-Abl phosphokinase in a xenograft model.
The purpose of this study was to determine whether the Bcr-Abl tyrosine kinase can be assessed by gamma-imaging using an 111In-labeled anti-phosphotyrosine (APT) antibody, and if the response to treatment with imatinib could be detected using this imaging technique. APT antibody was labeled with 111In using ethylenedicysteine (EC) as a chelator. To determine if 111In-EC-APT could assess a nonre...
متن کاملMolecular pathways: BCR-ABL.
Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders, including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL. ABL therefore represents a crucial target for new therapeutic strategies. Here, we summarize the molecular pathways that are abnormally activated by the oncoprotein. Such pathways may provide additional opportunities to ...
متن کامل1 Molecular pathways : BCR - ABL
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Aberrant Tyrosine kinase (TK) activity is critical in many hematological disorders, including chronic myeloid leukemia (CML) characterized by the constitutive activity of BCR-ABL. ABL therefore represented a crucial target for new therapeutic strategies. The molecular pathways abnormal...
متن کاملMolecular Pathways Molecular Pathways: BCR-ABL
Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders, including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL. ABL therefore represents a crucial target for new therapeutic strategies. Here, we summarize the molecular pathways that are abnormally activated by the oncoprotein. Such pathways may provide additional opportunities to ...
متن کاملAn In-House Method for Molecular Monitoring of BCR-ABL
OBJECTIVE At present, there are a limited number of facilities in Turkey that can provide reliable real-time quantitative(RQ)-PCR BCR-ABL results. The present study aimed to test a cost-effective, in-house method of BCR-ABL quantification,including verification of the method by RQ-PCR validation tests. MATERIAL AND METHODS BCR-ABL and ABL target sequences were cloned into pJET1.2 vectors, fro...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2009
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-08-0656